(including some early reviews and citation classics)


M.Tevfik DORAK

[Back to MHC]


See reviews:

A Short History of HLA (Thorsby A, Tissue Antigens 2009) and Historic Landmarks in Clinical Transplantation (Groth CG et al, World J Surg 2000)


Table 6: History of Tissue matching (Groth CG et al, World J Surg 2000)

Figure 1: Timeline of Research in the MHC and Human Genome (Vandiedonck & Knight, Brief Funct Genomic Proteomic 2009)


HALDANE JBS. The genetics of cancer. Nature 1933;132:265-7 (first postulate on immunological basis of tumour resistance; see Paigen, 2003)


GORER PA. The detection of antigenic differences in mouse erythrocytes by the employment of immune sera. Br J Exp Biol 1936;17:42-6 (definition of MHC)


GORER PA. The genetic and antigenic basis of tumour transplantation. Journal of Pathology & Bacteriology 1937;44:691-7 (link)


LITTLE CC. The genetics of tumor transplantation, pp. 279309 in Biology of the Laboratory Mouse, edited by G. D. SNELL. Dover, New York. 1941


GORER PA, LYMAN S, SNELL GD. Studies on the genetic and antigenic basis of tumour transplantation. Linkage between a histocompatibility gene and "fused" in mice. Proceedings of the Royal Society of London - Series B: Biological Sciences 1948;135:499-505


SNELL GD. Methods for the study of histocompatibility genes. J Genet 1948;49:87-108


SNELL GD. A fifth allele at the histocompatibility-2 locus of the mouse as determined by tumor transplantation. J Natl Cancer Inst 1951;11:1299-305


SNELL GD & HIGGINS GF. Alleles at the histocompatibility-2 locus in the mouse as determined by tumor transplantation. Genetics 1951;36:306-310 [PDF]


DAUSSET J & NENNA A. Presence d'une leuco-agglutinine dans le serum d'un cas d'agranulocytose chronique. CR Society for Biology 1952:140:1534-6


AMOS DB. The agglutination of mouse leukocytes by iso-immune sera. Br J Exp Path 1953;3:464-70


AMOS DB, GORER PA, MIKULSKA BM, BILLINGHAM RE, SPARROM EM. An antibody response to skin homographts in mice. Br J Exp Path 1954;35:203-8


AMOS DB, GORER PA, MIKULSKA ZB. An analyses of an antigenic system in the mouse (The H-2 system). Proc Royal Society B 1955;144:369-80 [Medline]


PAYNE R. Leukocyte agglutinins in human sera. Arch Intern Med 1957;99:587-91 (see Dausset & Nenna, 1952 and Amos, 1953)


WALFORD RL. The relation of anti-leukocyte antibodies to the homograft reaction: their occurrence in human sera. Transpl Bull 1958;5:556


SNELL GD. Histocompatibility genes of the mouse. I. Demonstration of weak histocompatibility differences by immunization and controlled tumor dosage. J Natl Cancer Inst 1958;20:787-824 (definition of MHC)

VAN ROOD JJ, EERNISSE JO, VAN LEEUWEN A. Leucocyte antibodies in sera from pregnant women. Nature 1958;181:1735-6 (see Dausset & Nenna, 1952; Amos, 1953 and Payne, 1957)

DAUSSET J. Iso-leuco-anticorps. Acta Haematologica 1959;20:156-66 (see the Citation Classic commentary)


RUSSELL IS, WINN HJ, AMOS DB. Histocompatibility Testing: report of a conference and workshop (Duke University). National Academy of Sciences Publication #1229. Washington DC. 1964 (First Histocompatibility Workshop Report)


VAN ROOD JJ & VAN LEEUWEN A. Leukocyte grouping: a method and its application. J Clin Invest 1963;42:1382-90 (PDF)


VAN LEEUWEN A, EERNISSE JG, VAN ROOD JJ. A new leucocyte group with two alleles: leucocyte group five. Vox Sang 1964;9:431-46


PAYNE R, TRIPP M, WEIGLE J, BODMER WF, BODMER JG. A new leukocyte isoantigen system in man. Cold Spring Harbor Symp Quant Biol 1964;29:285-95 (link)


BACH F, HIRSCHHORN K. Lymphocyte interaction: a parennial histocompatibility test in vitro. Science 1964;143:813-4 (MLC test)


STICKEL DL, AMOS DB, ROBINSON RR, GLENN JF, ZMIJEWSKI CM, METZGAR RS, HAYES CP. Renal Transplantation with donor recipient tissue-matching: Preliminary report of first case in North Carolina. N.C. Med J 1965;26:379-83


BODMER WF, BODMER JG, ADLER S, PAYNE R, BIALEK J. Genetics of '4' and 'LA' human leukocyte groups. Ann NY Acad Sci 1966;129:473-89


DAUSSET J, IVANYI P. COLOMBANI J, FEINGOLD N, LEGRAND L. Le systeme Hu-1: etudes genetiques de population et de familles. Nouv Rev Franc Hemat 1967;7:897-9


BACH FH, AMOS DB. Hu-1 major histocompatibility locus in man. Science 1967;156:1506-8 (link)


BACH F, AMOS DB. Phenotyphic expressions of the major histocompatibility locus in man (HLA): Leukocyte antigens and mixed leukocyte culture reactivity. J Exp Med 1968;128:623-39


PATEL R, MICKEY MR, TERASAKI PI. Serotyping for homotransplantation of kidneys from unrelated donors. New Eng J Med 1968;279: 501-6

KISSMEYER-NIELSEN F, SVEJGAARD A, HAUGE M. Genetics of the human HL-A transplantation system. Nature 1968;219:1116-9


KISSMEYER-NIELSEN F, SVEJGAARD A, AHRONS S, NIELSEN LS. Crossing-over within the HL-A system. Nature 1969;224:75-6


AMOS DB, YUNIS EJ. Human leukocyte antigenic specificity HLA-A3; frequency of occurrence. Science 1969:165:300


WALFORD R L, FINKELSTEIN S, HANNA C, COLLINS Z. Third sublocus in the HL-A human transplantation system. Nature 1969;224:74-5

MANN DL, ROGENTINE GN JR., FAHEY JL, NATHENSON SG. Molecular heterogeneity of human lymphoid (HL-A) alloantigens. Science 1969;163:1460-2


VAN ROOD JJ. Leucocyte grouping and organ transplantation. Br J Haematol 1969;16:211-20

VAN ROOD JJ. Tissue typing and organ transplantation. Lancet 1969;I:1142-6


FELLOUS M, DAUSSET J. Probable haploid expression of HL-A antigens on human spermatozoan. Nature 1970;225:191-3


KISSMEYER-NIELSEN F & THORSBY E. Human transplantation antigens. Transplant Rev 1970;4:1-176 (reporting name change from HL-A to HLA).


THORSBY E, SANDBERG L, LINDHOLM A, KISSMEYER-NIELSEN F. The HL-A system: evidence of a third sub-locus. Scand J Haemat 1970;7:195-200


TERASAKI PI (Ed). Histocompatibility Testing 1970. Baltimore: Williams & Wilkins, 1971, 351


YUNIS EJ, AMOS DB. Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci USA 1971; 68: 3031-5


YUNIS EJ, PLATE JN, WARD FE, SEIGLER HF, AMOS DB. Anomalous MLR responsiveness among siblings. Transplant Proc 1971:III:118


YUNIS EJ, AMOS DB. Three closely linked genetic systems relevant to transplantation. Proc Natl Acad Sci 1971:68:3031


AMOS DB, YUNIS EJ. A new interpretation of the major histocompatibility gene complexes of man and mouse. Cell Immunol 1971:2:517


BODMER WF. Evolutionary significance of the HL-A system. Nature 1972;237:139-45


WEITKAMP LR, VAN ROOD JJ, THORSBY E, BIAS WB, FOTINO M, LAWLER SD, DAUSSET J, MAYR WR, BODMER J, WARD FS, SEIGNALET J, PAYNE R, KISSMEYER-NIELSEN F, GATTI RA, SACHS JA, LAMM LU. The relation of parental sex and age to recombination in the HL-A system. Hum Hered 1973;23:197-205


SOLHEIM BG, BRATLIE A, SANDBERG L, STAUB-NIELSEN L, THORSBY E. Further evidence of a third HL-A locus. Tissue Antigens 1973;3: 439-53


YUNIS EJ, SEIGLER HF, SIMMONS RL, AMOS DB. HL-A typing, mixed leukocyte reactivity and skin graft survival in a family with a recombination at the HL-1 chromosomal region (major transplantation region). Transplantation 1973:15:435


YUNIS EJ, KRIVIT W, REINSMOEN M, AMOS DB. Inheritance of a recombinant HL-A haplotype and genetics of the HL-1 region in man. Nature 1974:248:517


LAMM LU, FRIEDRICH U, PETERSEN GB, JORGENSEN J, NIELSEN J, THERKELSEN AJ, KISSMEYER-NIELSEN F. Assignment of the major histocompatibility complex to chromosome no. 6 in a family with a pericentric inversion. Hum Hered 1974;24: 273-84


ZINKERNAGEL RM & DOHERTY PC. Restriction of in-vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system. Nature 1074;248:701-702 [Medline]


LONG MA, HANDWERGER BS, AMOS DB, YUNIS EJ. The genetics of cell-mediated lympholysis. J Immunol 1976:117:2092


FRANCKE U, PELLEGRINO MA. Assignment of the major histocompatibility complex to a region of the short arm of human chromosome 6. Proc Nat Acad Sci USA 1977; 74: 1147-1151


GALFRE G, HOWE SC, MILSTEIN C, BUTCHER GW, HOWARD JC. Antibodies to major histocompatibility antigens produced by hybrid cell lines. Nature 1977;266:550-2


ROBINSON MA, NOREEN HJ, AMOS DB, YUNIS EJ. Target antigens of cell-mediated lympholysis discrimination of HLA subtypes by cytotoxic lymphocytes. J Immunol 1978:121:1486


BLUMENTHAL MN, AMOS DB, NOREEN HJ, MENDELL NR, YUNIS EJ. Genetic mapping of Ir locus in man: linkage to second locus of HLA. Science 1978:184:1301


BRODSKY FM, PARHAM P, BARNSTABLE CJ, CRUMPTON MJ, BODMER WF. Monoclonal antibodies for analysis of the HLA system. Immunol Rev 1979;47:3-61


KLEIN J. The major histocompatibility complex of the mouse. Science 1979;203:516-21


DAUSSET J. The major histocompatibility complex in man: past, present, and future concepts. Science 1981;213:1469-74 (Nobel Lecture; see also SNELL GD (Nobel Lecture) and BENACERRAF B (Nobel Lecture)


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M.Tevfik Dorak, MD, PhD

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