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HLA and Leukemia Associations


M.Tevfik Dorak, MD, PhD


PowerPoint presentation on MHC & Leukemia Associations in Humans


Here you will find a list of my published papers on the immunogenetics of leukaemia.  Also relevant are the following sites:

Abstracts of our Current Research


Frequently Asked Questions about HLA-DR53 and Leukemia     HLA-DR53 Fact File 


Abstracts of Other Molecular HLA Studies in Childhood ALL 


Statistical Analysis in HLA and Disease Association Studies 


Full Publication List with Abstracts (may take few minutes)


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Conserved Extended Haplotypes of the Major Histocompatibility Complex: Further Characterization

Genes & Immunity, Sept 2006


Commentary: HFE H63D variant and leukemia

Leukemia & Lymphoma (in press)


Hemochromatosis Gene in Childhood Leukemia [HuGE Review]

M Tevfik Dorak, Alan K Burnett, Mark Worwood

Genetics in Medicine 2005;7(3):159-68 (Full-text)

* * *


Major Histocompatibility Complex, t-Complex, and Leukemia

(Dorak & Burnett.

Cancer Causes & Control 3:273-282)

MHC has a recessive influence in the development of leukaemia and abortions

Leukemia susceptibility genotype should have a protective mechanism to escape natural selection

In analogy to the mouse t-complex, this protective mechanism may be TRD

Haplotypes showing TRD may be associated with leukaemia in homozygous form


Human MHC Contains Several Leukemia Susceptibility Genes

(Dorak et al. Leuk & Lymph 12:211-222)

No HLA/MHC allele has any association with CML

HLA-DR53 haplotypes show TRD in controls (kidney transplant patients’ families)

Homozygosity for HLA-DR53 accelerates the development of CML

(similar to the interactive influence of -cross-reactive- H-2k in mice)

Homozygous MHC Genotypes and Longevity

(Dorak et al. Hum Hered 44:271-278)

Homozygosity for HLA-DR53 is increased in young males and shows a significant decrease with age

Homozygosity for the HLA-DR53 - HSP70*L haplotype shows difference between the gender groups

Molecular Mimicry of an HLA-DR53 Epitope by Viruses [letter]

(Dorak & Burnett. Immunol Today 15:138-139)

HVR3-encoded epitope of HLA-DR53 is mimicked by viruses

(7/7 amino acids [LLERRRA] by adenovirus & EBV)


Nature of HLA-Associated Predisposition to Childhood ALL

(Dorak et al. Leukemia 9:875-878)

Homozygosity for HLA-DR53 is increased in boys with ALL (compared to the adult frequency)

[see also Dorak et al. 1999a, 2000, 2002b]


Influence of the MHC on Age at Onset of CLL

(Dorak et al. Int J Cancer 65:134-139)

Homozygosity for HLA-DR53 accelerates the development of CLL, whereas, homozygosity for HLA-DR52 delays the onset of CLL

HLA and Hodgkin's disease [letter]

(Dorak et al. Leukemia 1996;10:1671-2)

Criticism of an HLA-disease association study in terms of design and data analysis

The Implications for Childhood Leukemia of Infection with Adenovirus [Opinion]

(Dorak MT. Trends Microbiol 4:60-63) (PDF)

The long-suspected viral link in childhood ALL may be adenovirus

[as a promoter of pre-existing mutant clones that have arisen spontaneously]

Role of the Major Histocompatibility Complex in the Genetics of Human Leukemia [Review]

(Dorak MT. Turkish Journal of Medical Sciences 1996;26:119-123)


HLA and Hodgkin's disease: Reply to Taylor and Gokhale [letter]

(Dorak et al. Leukemia 11:892-893)

A mini-review of our data on HLA-DR53 association in leukaemias


A Sex-Specific Difference in Homozygosity for HLA-DR53 in Newborns

(Sunguroglu A et al.  Turk J Ped 1998;40:211-6)

Among 134 newborns in Turkey, the homozygosity rates for HLA-DR53 are 12.3% (boys) and 3.3% (girls) (P=0.05) with an increased homozygosity in boys compared to the expected rate (P=0.02)


Unravelling an HLA-DR Association in Childhood Acute Lymphoblastic Leukemia

(Dorak et al. Blood 1999a;94:694-700;   full-text)

The first PCR-based HLA-DRB1/3/4/5 analyses of childhood ALL (n=114) and local newborn controls (n=325)

(see also Dorak et al, 2002b)

The C282Y Mutation of HFE is Another Male-Specific Risk Factor for Childhood Acute Lymphoblastic Leukemia [letter]

(Dorak et al. Blood 1999b;94:3957-8;   full-text)


A Search for a Leukaemia Susceptibility Gene in the HLA Complex  ..

 PhD Abstract ..

Completion of the study presented in a Blood paper (Dorak et al, 1999a). The analysis of the control group also revealed interesting findings (Dorak et al, 2002c).


Identification of a female-specific susceptibility genotype in childhood ALL and confirmation of the male-specific susceptibility marker in Turkish patients.

Both are presented as abstracts.



Hemochromatosis Gene in Leukemia and Lymphoma

(Dorak, Burnett, Worwood, 2002a, Leukemia & Lymphoma 2002;43(3):467-477; PubMed)

A Male-Specific Increase in the HLA-DRB4 (DR53) Frequency in High-Risk and Relapsed Childhood ALL

(Dorak et al, 2002b, Leukemia Research 2002;26(7):651-6; PubMed)

Increased Heterozygosity for MHC Class II Lineages in Newborn Males

(Dorak et al, 2002c, Genes & Immunity 2002;3(5):263-9, PubMed)


HLA System Affects the Age-at-Onset in Chronic Myeloid Leukemia

(Oguz, Kalayoglu, Diler, Tozkir, Sargin, Carin & Dorak, Am J Hematol. 2003;73(4):256-62, PubMed) (PDF) .

Medline search for papers by Dorak MT



Great North Run in Aid of Children with Leukemia

M.Tevfik Dorak, MD PhD

Last updated on 29 September 2006

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